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[亲子关系血型鉴定的实践:排除效力低的系统;血清学排除的证据;生物统计学问题。对H. 里特于1973年发表在《家庭法杂志》第121期上一篇论文的评论(作者译)]

[Praxis of the blood group opinion of parentage: systems with low exclusions potency; evidence of serological exclusion; biostatistical problems. Comments to a paper of H. Ritter in FamRZ 1973, 121 (author's transl)].

作者信息

Hummel K

出版信息

Z Rechtsmed. 1975 Sep 5;76(1):49-61. doi: 10.1007/BF02116798.

DOI:10.1007/BF02116798
PMID:814739
Abstract

Blood group systems with a rare second allel are in praxis ineffective and therefore uneconomical because of their low exclusion potency as well as their low serostatistical value. The evidence of exclusion in particular blood group systems is fixed by the German "Richtlinien". With the new German law, however, one has to differentiate between the requirements in respect of the "offenbar unmöglich" ("fatherhood evidently impossible") in cases of extramatriomonial children, and those in respect of "schwerwiegende Zweifel" ("serious doubts in fatherhood") in cases of illegitimate children. The serostatistical results can give an indication on non-fatherhood, but in no case a real exclusion of paternity. Further evidence, as an anthropological or an HL-A expert opinion, is necessary to decide if the negative hint is reliable or not. To evaluate blood group (and HL-A) findings biostatistically, one uses the BAYES' Theorem with ESSEN-MOLLER's frequencies X and Y (in two-hypothesis cases). As prior plausibility one sets ESSEN-MOLLER's normative 0.5 or a realistic value, calculated from a concrete material of forensic cases. Statistical values on the basis of the exclusion chance as A, WA, Z, P and x do not give the whole information, because the phenotype of the man is not (or not fully) regarded. Therefore these values are of no use in serostatistical evaluation. With appropriate frequencies it is possible to calculate the probability of paternity also in cases in which foreign people is involved. If foreign frequencies are not available, the German "Richtlinien" allow to use european frequencies, if the involved people shares the caucasoid (europid) race.

摘要

具有罕见第二等位基因的血型系统在实际应用中效率低下,因此不经济,因为它们的排除效力低且血清统计学价值低。特定血型系统中的排除证据由德国的“指导方针”确定。然而,根据德国新法律,对于非婚生子女的“显然不可能”(“显然不可能是父亲”)情况和非婚生子女的“严重怀疑”(“对父亲身份有严重怀疑”)情况,必须区分要求。血清统计学结果可以表明非父身份,但绝不能真正排除亲子关系。要确定负面提示是否可靠,还需要进一步的证据,如人类学或HL - A专家意见。为了对血型(和HL - A)结果进行生物统计学评估,在双假设情况下使用带有埃森 - 莫勒频率X和Y的贝叶斯定理。作为先验可信度,设定埃森 - 莫勒的标准值0.5或根据具体法医案例材料计算出的实际值。基于排除机会的统计值,如A、WA、Z、P和x,并不能提供全部信息,因为没有(或没有完全)考虑男性的表型。因此,这些值在血清统计学评估中没有用处。使用适当的频率,即使涉及外国人的情况,也可以计算亲子关系的概率。如果没有外国频率,德国的“指导方针”允许在相关人员属于高加索人种(欧洲人种)的情况下使用欧洲频率。

相似文献

1
[Praxis of the blood group opinion of parentage: systems with low exclusions potency; evidence of serological exclusion; biostatistical problems. Comments to a paper of H. Ritter in FamRZ 1973, 121 (author's transl)].[亲子关系血型鉴定的实践:排除效力低的系统;血清学排除的证据;生物统计学问题。对H. 里特于1973年发表在《家庭法杂志》第121期上一篇论文的评论(作者译)]
Z Rechtsmed. 1975 Sep 5;76(1):49-61. doi: 10.1007/BF02116798.
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[Highly different values for the plausibility of fatherhood and for the exclusion chance (author's transl)].[关于父权合理性及排除几率的差异极大的值(作者译)]
Z Rechtsmed. 1978 Jul 27;81(3):217-22. doi: 10.1007/BF00201270.
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[Blood group opinion and judicial judgement 1. 250 paternity cases 1965-1970 (author's transl)].[血型鉴定意见与司法判决 1. 1965 - 1970年的250例亲子鉴定案件(作者译)]
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On the theory and practice of Essen-Möller's W value and Gürtler's paternity index (PI).论埃森 - 默勒W值和居尔特勒父权指数(PI)的理论与实践。
Forensic Sci Int. 1984 May;25(1):1-17. doi: 10.1016/0379-0738(84)90010-0.
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[Calculation of the plausibility of fatherhood on the basis of blood group results in special cases, using weighted Y/X values in order to respect the results from siblings of included persons. Case 1: Probablity of parentage for a deceased man, computed on the base of blood group findings by the child, his mother and the mother and 3 siblings of the deceased man disputed as father (author's transl)].[基于血型结果计算特殊情况下父子关系的似然性,使用加权Y/X值以考虑纳入人员兄弟姐妹的结果。案例1:根据孩子、其母亲以及被质疑为父亲的已故男子的母亲和3个兄弟姐妹的血型检测结果计算已故男子的亲子关系概率(作者译)]
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Mathematical aspects of the paternity index I = X/Y, especially in relation to the chance of non-exclusion of non-fathers.父权指数I = X/Y的数学方面,特别是与非父亲不能被排除的概率相关的方面。
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[Diagnosis of paternity by deduction of the probable genotype of the deceased person from the relatives--in addition to the examination of the Essen-Möller value and diagnosis of paternity based on the probability distribution of log (Y/X)].通过从亲属推导死者可能的基因型来诊断亲子关系——除了检查埃森-默勒值以及基于对数(Y/X)概率分布进行亲子关系诊断之外。
Nihon Hoigaku Zasshi. 1991 Aug;45(4):277-87.
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[Biostatistical evaluation of HLA-A, B findings in cases with suspected recombination].[疑似重组病例中HLA-A、B结果的生物统计学评估]
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本文引用的文献

1
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Dtsch Z Gesamte Gerichtl Med. 1968;64(2):127-46.