Köhler W, Djikidse E K, Otto R
Zentralbl Bakteriol Orig A. 1975 Oct;233(2):163-70.
Rhesus monkeys are often used as experimental animals. Many clinical and biochemical parameters are known but there are only few papers dealing with the normal values of antistreptolysin O (ASL). Informations about antistreptococcal antibodies are necessary in order to follow the course of immunization and infection experiments. When non-absorbed sera were used, the mean value of antistreptolysin O in clinically healthy rhesus monkeys (Macacus rhesus) amounted to 178 +/- 52 ASU. After absorption with dextran sulphate, the mean value was 90 +/- 20 ASU. Absorption with dextransulphate is a necessary prerequisite to exact determinations of antistreptolysin titres because it removes unspecific inhibitors of streptolysin O. In the sera of rhesus monkey more inhibitors were present than in human sera. On an average, in monkeys 55% of the material reacting with streptolysin O was an inhibitor, compared with about 40% in human sera. As a result of common infections with streptolysin O-producing streptococcal groups C and G antistreptolysin titres can frequently be seen to increase above the average normal value. Using non-absorbed and dextran sulphate absorbed sera, respectively 350 and 200 ASU must be regarded as the normal upper limits for serum antistreptolysin-titres.
恒河猴常被用作实验动物。许多临床和生化参数是已知的，但关于抗链球菌溶血素O（ASO）正常值的论文却很少。为了跟踪免疫和感染实验的进程，了解抗链球菌抗体的信息是必要的。当使用未吸收的血清时，临床健康的恒河猴（猕猴）抗链球菌溶血素O的平均值为178±52抗链球菌溶血素单位（ASU）。用硫酸葡聚糖吸收后，平均值为90±20 ASU。用硫酸葡聚糖吸收是准确测定抗链球菌溶血素滴度的必要前提，因为它能去除链球菌溶血素O的非特异性抑制剂。恒河猴血清中存在的抑制剂比人血清中的更多。平均而言，在猴子中，与链球菌溶血素O反应的物质中有55%是抑制剂，而在人血清中约为40%。由于经常感染产生链球菌溶血素O的C组和G组链球菌，抗链球菌溶血素滴度常常会升高到平均正常值以上。分别使用未吸收和经硫酸葡聚糖吸收的血清时，血清抗链球菌溶血素滴度的正常上限必须视为350和200 ASU。
