Ambrosio A M, Feuillade M R, Gamboa G S, Maiztegui J I
Instituto Nacional de Enfermedades Virales Humanas, Pergamino, Argentina.
Am J Trop Med Hyg. 1994 Mar;50(3):381-6. doi: 10.4269/ajtmh.1994.50.381.
The activity of lymphocytic choriomeningitis virus (LCMV) in the endemic area of Argentine hemorrhagic fever has been previously reported and represents the first evidence of the coexistence of two arenaviruses pathogenic for humans, Junin and LCMV, in the same geographic area. Data are presented on the prevalence of LCMV human infection in a 10,000-km2 area located in Santa Fe Province, Argentina. Study subjects were males, 15-65 years old, living and/or working in the rural area of 41 localities. One serum sample was obtained from each 7,227 volunteers from a total population of 21,340 individuals with the described features. Antibodies to LCMV were assessed by means of an indirect immunofluorescence assay. These antibodies were found in 172 serum samples, with titers ranging from 1:8 to 1:128 (geometric mean titer = 15.03), and a mean percentage of infection of 2.38%. A significantly different distribution of positive individuals was found between the eastern (1.54%) and western (3.07%) borders of the region studied (P < 0.0003). The higher percentage of infection on the western side was due to the existence of two clusters of counties with a mean percentage of 6.06% that was significantly different from the 1.67% obtained in the rest of the study area (P < 0.0003). These results provide new information on the LCMV activity in Argentina, and update the evidence on the coexistence of two arenaviruses in the same region of Argentina. This circumstance increases the probability of generation of viral reassortants with changes that could determine the need for new therapeutic and/or preventive strategies for arenaviral diseases.
先前已有报道称，淋巴细胞性脉络丛脑膜炎病毒（LCMV）在阿根廷出血热的流行地区有活动，这是两种对人类致病的沙粒病毒——胡宁病毒和LCMV——在同一地理区域共存的首个证据。本文给出了位于阿根廷圣菲省一个10000平方公里区域内LCMV人类感染的流行情况数据。研究对象为年龄在15至65岁之间、在41个地区农村生活和/或工作的男性。从具有上述特征的21340名个体的总人口中，每7227名志愿者采集一份血清样本。通过间接免疫荧光试验评估针对LCMV的抗体。在172份血清样本中发现了这些抗体，滴度范围为1:8至1:128（几何平均滴度 = 15.03），平均感染率为2.38%。在所研究区域的东部边界（1.54%）和西部边界（3.07%）之间，阳性个体的分布存在显著差异（P < 0.0003）。西侧较高的感染率是由于存在两个县的集群，其平均感染率为6.06%，与研究区域其他地方获得的1.67%有显著差异（P < 0.0003）。这些结果提供了关于阿根廷LCMV活动的新信息，并更新了阿根廷同一地区两种沙粒病毒共存的证据。这种情况增加了产生病毒重配体的可能性，其变化可能决定需要针对沙粒病毒疾病采取新的治疗和/或预防策略。
