Chariot P, Monnet I, Mouchet M, Rohr M, Lefaucheur J P, Dubreuil-Lemaire M L, Chousterman M, Gherardi R
Département de Pathologie (Neuropathologie), Hôpital Henri Mondor, Créteil, France.
Arthritis Rheum. 1994 Apr;37(4):583-6. doi: 10.1002/art.1780370421.
To evaluate the use of the lactate: pyruvate ratio as a test for the detection of zidovudine myopathy.
Twenty consecutive human immunodeficiency virus-infected patients with muscle involvement and 20 without muscle involvement were studied prospectively. Blood lactate and pyruvate levels and serum creatine kinase levels were tested, muscle involvement was assessed both clinically and electrophysiologically, and muscle biopsy was performed in patients with myopathy.
Nine patients had biopsy-proven zidovudine myopathy. All 9 had a high lactate:pyruvate ratio, with elevations on 2 of 2 determinations in 6 patients and on 1 of 2 in 3 patients. Two of 11 patients with other myopathies and 2 of 20 patients without myopathy had a high lactate:pyruvate ratio on 1 of 2 determinations.
The lactate:pyruvate ratio, when determined repeatedly, is a sensitive test for detecting mitochondrial muscular toxicity of zidovudine.
评估乳酸与丙酮酸比值作为检测齐多夫定肌病的一项检测指标的效用。
对连续20例有肌肉受累的人类免疫缺陷病毒感染患者和20例无肌肉受累的患者进行前瞻性研究。检测血乳酸和丙酮酸水平以及血清肌酸激酶水平，从临床和电生理方面评估肌肉受累情况，并对肌病患者进行肌肉活检。
9例患者经活检证实为齐多夫定肌病。所有9例患者的乳酸与丙酮酸比值均较高，6例患者的2次检测结果均升高，3例患者的2次检测中有1次升高。11例患有其他肌病的患者中有2例，20例无肌病的患者中有2例在2次检测中有1次乳酸与丙酮酸比值较高。
重复测定时，乳酸与丙酮酸比值是检测齐多夫定线粒体肌肉毒性的一项敏感检测指标。
