Leprini A, Garaventa G, Leprini A E, Pallestrini E, Pallestrini E A
Istituto di Anatomia Umana, Università degli Studi e Ospedale S. Martino, Genova.
Boll Soc Ital Biol Sper. 1993 Jun;69(6):395-401.
In the last years nasal polyps have been studied by several authors with different methodologies; however, their etiology is still unclear. In this paper we have analyzed in four nasal polyps of fibrous type, the HLA class II (HLA-DR, DP, DQ) molecule expression by means of immunohistochemical techniques (immunoperoxidase and immunophosphatase). A strong inflammatory cell infiltration, a percentage increase of both HLA-DR+ and HLA-DQ+ cells (normal nasal mucous membrane stroma infiltrating cells: DR+ < 40%, DP+ < 2%, DQ+ < 3%; fibrous polyps infiltrating cells: DR+ = 68%, DP+ < 2, DQ+ = 7%) as well as a clear positivity for DR expression of both surface and glandular epithelia were observed in all polyps. Furthermore, in the stalk area of one of the studied polyps DR+DQ+ cells with macrophagic features and having tight. connections with the vessels were observed. The scanty vascularization with the presence of activated mononuclear and mast cells might be responsible for polyp growth by locally producing an anomalous concentration of growth factors.
近年来，多位作者采用不同方法对鼻息肉进行了研究；然而，其病因仍不明确。在本文中，我们通过免疫组织化学技术（免疫过氧化物酶法和免疫磷酸酶法）分析了4例纤维型鼻息肉中HLA - II类（HLA - DR、DP、DQ）分子的表达情况。所有息肉均观察到强烈的炎性细胞浸润，HLA - DR⁺和HLA - DQ⁺细胞百分比增加（正常鼻黏膜基质浸润细胞：DR⁺＜40%，DP⁺＜2%，DQ⁺＜3%；纤维性息肉浸润细胞：DR⁺ = 68%，DP⁺＜2%，DQ⁺ = 7%），同时表面和腺上皮的DR表达均呈明显阳性。此外，在其中1例研究息肉的蒂部区域观察到具有巨噬细胞特征且与血管紧密相连的DR⁺DQ⁺细胞。血管化不足以及活化的单核细胞和肥大细胞的存在可能通过局部产生异常浓度的生长因子而导致息肉生长。
