Leprini A, Garaventa G, Bottero S, Leprini A E, Pallestrini E, Castello E, Pallestrini E A
Istituto di Anatomia Umana e Clinica ORL, Università degli Studi di Genova.
Boll Soc Ital Biol Sper. 1990 Nov;66(11):1073-80.
In this study fibrous nasal polyps, obtained from four patients, were analyzed by means of immunocytochemical methods for the presence of interstitial hematic cell infiltrate and HLA-DR molecule expression. This histologic type accounted for 36.4% of nasal polyps studied. Our results demonstrated that cells belonging to monocyte-macrophage lineage were mainly detected within fibrous and edematous zones (greater than 50%), whereas T cells were found within the subepithelial peripheral connective tissue (greater than 60%). Surface and gland epithelial cells appeared to be more intensely stained for HLA-DR molecules than nasal epithelium of normal subjects, thus indicating that the intensity of HLA-DR molecule expression correlated with the presence of a hematic cell infiltrate. Nasal polyps are a frequent pathology whose etiology has not yet been completely clarified. The present study provides additional information about the fibrous polyp structure and can support some speculations on the nasal polyp etiology.
在本研究中，对从4例患者获取的纤维性鼻息肉采用免疫细胞化学方法分析间质血细胞浸润情况及HLA-DR分子表达。这种组织学类型占所研究鼻息肉的36.4%。我们的结果表明，单核细胞-巨噬细胞谱系的细胞主要在纤维性和水肿区域被检测到（超过50%），而T细胞则在基底膜下周边结缔组织中被发现（超过60%）。表面和腺上皮细胞HLA-DR分子染色似乎比正常受试者的鼻上皮更强烈，因此表明HLA-DR分子表达强度与血细胞浸润的存在相关。鼻息肉是一种常见疾病，其病因尚未完全阐明。本研究提供了关于纤维性息肉结构的更多信息，并能支持对鼻息肉病因的一些推测。
