Krupin T, Podos S M, Becker B, Newkirk J B
Am J Ophthalmol. 1976 Feb;81(2):232-5. doi: 10.1016/0002-9394(76)90737-6.
A valve implant for glaucoma incorporated upper and lower intraocular pressure limits for outflow. The device consisted of an open Supramid tube sealed to a Silastic tube with a slit valve. The valve implants had opening pressures of 11 to 16 mm Hg and closing pressures 1 to 3 mm Hg lower. A surgical technique was developed in monkey eyes and applied later in modified form to three patients with glaucoma. In four of seven monkey eyes the implants remained in place and were patent for over one year. Follow-up studies were carried out for over six months in the three patients. In two patients the valve implants were functioning with controlled intraocular pressures. In one patient the implant migrated posteriorly. This was replaced by using a new valve and a buried fixation suture and has since functioned without problem. The valve implants were well tolerated and offered possibilities for predictable intraocular pressures after glaucoma surgery.
一种用于青光眼的瓣膜植入物设定了上、下眼内压流出限度。该装置由一根开放的Supramid管和一根带有裂隙瓣膜的硅胶管密封连接而成。瓣膜植入物的开放压力为11至16毫米汞柱，关闭压力低1至3毫米汞柱。在猴眼中开发了一种手术技术，后来以改良形式应用于三名青光眼患者。七只猴眼中有四只，植入物保持在位且通畅超过一年。对三名患者进行了超过六个月的随访研究。两名患者的瓣膜植入物能使眼内压得到控制。一名患者的植入物向后移位。通过使用新瓣膜和埋藏固定缝线进行了更换，此后功能正常。瓣膜植入物耐受性良好，为青光眼手术后可预测的眼内压提供了可能。
