Carta F, Zanetti S, Pinna A, Sotgiu M, Fadda G
Istituto di Clinica Oculistica, Università di Sassari, Italy.
Br J Ophthalmol. 1994 Mar;78(3):206-8. doi: 10.1136/bjo.78.3.206.
Sixty two patients diagnosed as having adult chlamydial ophthalmia were treated with oral doxycycline and roxithromycin in association and tetracycline eye wash for 2 weeks. Chlamydial ophthalmia was diagnosed by laboratory detection of the micro-organism in ocular specimens using direct immunofluorescent monoclonal antibody staining for Chlamydia trachomatis, chlamydial culture in cycloheximide treated McCoy cells, and Giemsa staining. An immunoenzymatic method for detection of specific IgG and IgA in patients' serum was used as an additional test to confirm the diagnosis. All patients were reexamined 3 weeks after completing their course of antibiotics and in the case of persistent infection a further course of treatment was given. With this treatment regimen 48 out of 62 patients (77.4%) were cured after three courses. Because of the risks of an inadequate response to therapy, we recommend a proper post-treatment follow up in all patients with chlamydial eye infections.
62例被诊断为成人衣原体性眼炎的患者联合口服强力霉素和罗红霉素，并使用四环素洗眼液治疗2周。衣原体性眼炎通过实验室检测眼部标本中的微生物来诊断，采用针对沙眼衣原体的直接免疫荧光单克隆抗体染色、在经放线菌酮处理的McCoy细胞中进行衣原体培养以及吉姆萨染色。采用免疫酶法检测患者血清中的特异性IgG和IgA作为辅助检查以确诊。所有患者在完成抗生素疗程后3周进行复查，对于持续感染的患者给予进一步治疗疗程。采用这种治疗方案，62例患者中有48例（77.4%）在三个疗程后治愈。由于存在治疗反应不足的风险，我们建议对所有衣原体眼部感染患者进行适当的治疗后随访。
