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编码小鼠维生素K依赖蛋白S的cDNA的克隆与测序。

Cloning and sequencing of a cDNA encoding the murine vitamin K-dependent protein S.

作者信息

Chu M D, Sun J, Bird P

机构信息

Department of Medicine, Monash Medical School, Box Hill Hospital, Australia.

出版信息

Biochim Biophys Acta. 1994 Apr 6;1217(3):325-8. doi: 10.1016/0167-4781(94)90294-1.

DOI:10.1016/0167-4781(94)90294-1
PMID:8148380
Abstract

A cDNA clone encoding the vitamin K-dependent protein S was isolated from a murine liver cDNA library. Sequencing revealed an open reading frame encoding a 634 amino acid mature protein. Comparison to human and bovine sequences showed a high degree of similarity and the conservation of key residues between the species.

摘要

从鼠肝cDNA文库中分离出一个编码维生素K依赖蛋白S的cDNA克隆。测序显示一个编码634个氨基酸成熟蛋白的开放阅读框。与人和牛的序列比较表明,物种之间具有高度相似性且关键残基保守。

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引用本文的文献

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Species-specific anticoagulant and mitogenic activities of murine protein S.鼠蛋白 S 的种属特异性抗凝和有丝分裂活性。
Haematologica. 2009 Dec;94(12):1721-31. doi: 10.3324/haematol.2009.009233. Epub 2009 Oct 8.
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Protein S is inducible by interleukin 4 in T cells and inhibits lymphoid cell procoagulant activity.蛋白S在T细胞中可被白细胞介素4诱导,并抑制淋巴细胞促凝活性。
Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11484-9. doi: 10.1073/pnas.94.21.11484.