Barker E, Fujimura S F, Fadem M B, Landay A L, Levy J A
Department of Medicine, University of California, San Francisco 94143-0128.
Clin Infect Dis. 1994 Jan;18 Suppl 1:S136-41. doi: 10.1093/clinids/18.supplement_1.s136.
Several aspects of cellular immunity in patients with clinically defined chronic fatigue syndrome (CFS) were evaluated and compared with those in healthy individuals. Flow cytometric analyses revealed normal expression of total T (CD3+), B (CD19+), and NK (natural killer) (CD16+, CD56+) markers on the surface of peripheral blood mononuclear cells (PMC) from patients with CFS. However, compared with those of healthy individuals, patients' CD8+ T cells expressed reduced levels of CD11b and expressed the activation markers CD38 and HLA-DR at elevated levels. In many of the individuals in whom expression of CD11b was reduced the expression of CD28 was increased. These findings indicate expansion of a population of activated CD8+ cytotoxic T lymphocytes. A marked decrease in NK cell activity was found in almost all patients with CFS, as compared with that in healthy individuals. No substantial abnormalities in monocyte activity or T cell proliferation were observed. The results of this study suggest that immune cell phenotype changes and NK cell dysfunction are common manifestations of CFS.
对临床诊断为慢性疲劳综合征（CFS）患者的细胞免疫的几个方面进行了评估，并与健康个体进行了比较。流式细胞术分析显示，CFS患者外周血单核细胞（PMC）表面的总T（CD3 +）、B（CD19 +）和NK（自然杀伤）（CD16 +、CD56 +）标志物表达正常。然而，与健康个体相比，患者的CD8 + T细胞表达的CD11b水平降低，而活化标志物CD38和HLA - DR的表达水平升高。在许多CD11b表达降低的个体中，CD28的表达增加。这些发现表明活化的CD8 + 细胞毒性T淋巴细胞群体扩大。与健康个体相比，几乎所有CFS患者的NK细胞活性均显著降低。未观察到单核细胞活性或T细胞增殖有实质性异常。本研究结果表明，免疫细胞表型改变和NK细胞功能障碍是CFS的常见表现。
