Huang Y, Majumdar S, Genant H K, Chan W P, Sharma K R, Yu P, Mynhier M, Miller R G
Department of Radiology, University of California, San Francisco.
J Magn Reson Imaging. 1994 Jan-Feb;4(1):59-64. doi: 10.1002/jmri.1880040113.
Magnetic resonance imaging and maps of T1 and T2 values were used to study muscle composition in Duchenne muscular dystrophy (DMD). The mean T2 of anterior tibial muscle was 27 msec in healthy control subjects and 43 msec with increased fatty infiltration in DMD patients. In stronger DMD patients, the distribution of muscle T2 values was narrow, centered at 27 msec as in the controls, with a nonoverlapping fat peak centered at 49 msec. In weaker DMD patients, the width of the muscle T2 peak increased and the peak shifted toward the fat peak. Mean muscle T1 decreased from 1.7 to 0.6 second with increasing fatty infiltration. These results show that quantitative T1 and T2 maps may be used to assess muscle status and monitor DMD progression.
利用磁共振成像以及T1和T2值图谱研究杜氏肌营养不良症（DMD）患者的肌肉组成。健康对照受试者胫前肌的平均T2值为27毫秒，而DMD患者因脂肪浸润增加，该值为43毫秒。在病情较重的DMD患者中，肌肉T2值分布较窄，以27毫秒为中心，如同对照组，脂肪峰不重叠，以49毫秒为中心。在病情较轻的DMD患者中，肌肉T2峰变宽，且峰值向脂肪峰偏移。随着脂肪浸润增加，肌肉平均T1值从1.7秒降至0.6秒。这些结果表明，定量T1和T2图谱可用于评估肌肉状态并监测DMD的进展。
