Wapniarz M, Lehmann R, Banik N, Radwan M, Klein K, Allolio B
Medisinische Klinik, Universität Würzburg, Germany.
Bone Miner. 1993 Dec;23(3):243-52. doi: 10.1016/s0169-6009(08)80101-8.
It has been reported that apparent velocity of ultrasound (AVU) at the patella discriminates as well between osteoporotic and normal subjects as measurement of bone mineral density (BMD) using dual photon absorptiometry. To investigate the relationship between AVU and peak bone mass, we compared AVU (Signet, Osteo-Technology, Framingham, MA) at the patella and BMD (QDR 1000, Hologic, Waltham, MA) at the lumbar spine in a large sample of healthy males and females. The study population consisted of 153 males (aged 20-60 years) and 129 premenopausal females (aged 20-52 years). Vertebral BMD showed no significant difference between males and females (1.03 +/- 0.16 g/cm2 for males vs. 1.07 +/- 0.14 g/cm2 for females, NS), while AVU values were significantly higher in males compared with females (1967 +/- 64 m/s vs. 1938 +/- 76 m/s, P < 0.05). In men there was a significant decrease in BMD with aging (r = -0.27, P < 0.05), in premenopausal females we found no age-related change in BMD. Similarly in males AVU decreased significantly with age (r = -0.2, P < 0.05), whereas in females AVU values showed relative stability over the age range. There was a significant correlation between AVU and BMD (r = 0.36 for males, r = 0.34 for females, P < 0.05). Our study demonstrates only a weak correlation between AVU at that patella and BMD at the lumbar spine, supporting the view that AVU not only reflects bone quantity but possibly also qualitative properties of bone structure. The sex difference in AVU but not in BMD suggests that the trabecular bone at the patella differs significantly from axial trabecular bone. The identical peak BMD at the lumbar spine for young males and females underscores the importance of the menopause for later manifestation of vertebral fractures.
据报道，髌骨处的超声表观速度（AVU）在区分骨质疏松症患者和正常受试者方面与使用双光子吸收法测量骨矿物质密度（BMD）的效果相当。为了研究AVU与峰值骨量之间的关系，我们在一大群健康男性和女性中比较了髌骨处的AVU（Signet，Osteo-Technology，弗雷明汉，马萨诸塞州）和腰椎处的BMD（QDR 1000，Hologic，沃尔瑟姆，马萨诸塞州）。研究人群包括153名男性（年龄20 - 60岁）和129名绝经前女性（年龄20 - 52岁）。椎体BMD在男性和女性之间无显著差异（男性为1.03±0.16 g/cm²，女性为1.07±0.14 g/cm²，无显著性差异），而AVU值男性显著高于女性（1967±64 m/s对1938±76 m/s，P < 0.05）。在男性中，BMD随年龄增长显著降低（r = -0.27，P < 0.05），在绝经前女性中，我们未发现BMD有与年龄相关的变化。同样，在男性中AVU随年龄显著降低（r = -0.2，P < 0.05），而在女性中AVU值在该年龄范围内表现出相对稳定性。AVU与BMD之间存在显著相关性（男性r = 0.36，女性r = 0.34，P < 0.05）。我们的研究表明，髌骨处的AVU与腰椎处的BMD之间仅存在弱相关性，支持了AVU不仅反映骨量，还可能反映骨结构质量特性的观点。AVU存在性别差异而BMD不存在性别差异，这表明髌骨处的小梁骨与轴向小梁骨有显著差异。年轻男性和女性腰椎处相同的峰值BMD突出了绝经对椎体骨折后期表现的重要性。
