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哮喘患者常规自我监测呼气峰流速的有效性。格兰扁地区哮喘综合护理研究(GRASSIC)。

Effectiveness of routine self monitoring of peak flow in patients with asthma. Grampian Asthma Study of Integrated Care (GRASSIC).

出版信息

BMJ. 1994 Feb 26;308(6928):564-7.

Abstract

OBJECTIVE

To evaluate the effectiveness of routine self monitoring of peak flow for asthma outpatients.

DESIGN

Pragmatic randomised trial.

SETTING

Hospital outpatient clinics and general practices in north east Scotland.

MAIN OUTCOME MEASURES

Use of bronchodilators and inhaled and oral steroids; number of general practice consultations and hospital admissions for asthma; sleep disturbance and other restrictions on normal activity; psychological aspects of health including perceived control of asthma.

RESULTS

After one year there were no significant differences between patients randomised between self monitoring of peak flow and conventional monitoring. However, those given a peak flow meter recorded an increase in general practice consultations that was nearly significant. Among patients whose asthma was judged on entry to be more severe, those allocated to self monitoring used more than twice as many oral steroids (2.2; 95% confidence interval 1.1 to 4.6). Patients who already possessed a peak flow meter at the start of the study recorded higher morbidity over the course of the year than those eligible for randomisation.

CONCLUSION

Prescribing peak flow meters and giving self management guidelines to all asthma patients is unlikely to improve mortality or morbidity. Patients whose asthma is severe may benefit from such an intervention.

摘要

目的

评估哮喘门诊患者常规自我监测呼气峰值流速的有效性。

设计

实用随机试验。

地点

苏格兰东北部的医院门诊和全科诊所。

主要观察指标

支气管扩张剂、吸入和口服类固醇的使用情况;因哮喘进行的全科诊疗次数和住院次数;睡眠障碍及对正常活动的其他限制;健康的心理方面,包括对哮喘的感知控制。

结果

一年后,随机分为自我监测呼气峰值流速组和传统监测组的患者之间无显著差异。然而,配备了呼气峰值流速仪的患者进行的全科诊疗次数有所增加,接近显著水平。在入组时被判定哮喘病情较重的患者中,分配到自我监测组的患者口服类固醇的使用量是另一组的两倍多(2.2;95%置信区间1.1至4.6)。在研究开始时就已拥有呼气峰值流速仪的患者在这一年中的发病率高于符合随机分组条件的患者。

结论

给所有哮喘患者开出处方呼气峰值流速仪并给予自我管理指南不太可能改善死亡率或发病率。哮喘病情严重的患者可能会从这种干预措施中受益。

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