Sampelean D, Motocu M
Fourth Medical Clinic, Cluj-Napoca, Romania.
Rom J Intern Med. 1993 Oct-Dec;31(4):265-9.
The present study aimed to investigate the pathogenesis of altered glucose tolerance frequently observed in liver cirrhosis by means of oral glucose tolerance test (OGTT) and i.v. glucagon followed by determining the immunoreactive insulinemia and insulinogenic index (Seltzer). In these conditions of beta islet cells upper limit stimulation a low insulin secretion was found in decompensated liver cirrhosis with alteration of the glucose tolerance (DM or IGT) and a tendency toward hepatic resistance to i.v. glucagon.
本研究旨在通过口服葡萄糖耐量试验（OGTT）和静脉注射胰高血糖素，随后测定免疫反应性胰岛素血症和胰岛素生成指数（塞尔策），来研究肝硬化患者中常见的糖耐量改变的发病机制。在这些胰岛β细胞上限刺激的情况下，发现在失代偿期肝硬化且糖耐量改变（糖尿病或糖耐量受损）时胰岛素分泌较低，并且存在肝脏对静脉注射胰高血糖素抵抗的倾向。
