Motoyama T, Honma T, Watanabe H, Honma S, Kumanishi T, Abe S
Department of Pathology, Niigata University School of Medicine, Japan.
Virchows Arch B Cell Pathol Incl Mol Pathol. 1993;64(6):367-72. doi: 10.1007/BF02915136.
Systemic amyloidosis of the amyloid A (AA) type, is occasionally associated with various neoplasms, but the cause is still unclear. We obtained interleukin 6 (IL-6)-producing cells designated YO from a primary culture of a malignant peritoneal mesothelioma of epithelial type obtained from a 62-year-old woman. Post mortem examination revealed that the patient had systemic amyloidosis of the AA type. The supernatant media of YO cells, as well as recombinant human IL-6, successfully induced nonneoplastic liver cells to produce serum AA (SAA). Our data suggest that IL-6 produced by the tumor cells may have played an important role in the paraneoplastic syndrome of AA amyloidosis in this patient.
淀粉样蛋白A（AA）型系统性淀粉样变性偶尔与各种肿瘤相关，但病因仍不清楚。我们从一名62岁女性的上皮型恶性腹膜间皮瘤原代培养物中获得了产生白细胞介素6（IL-6）的细胞系YO。尸检显示该患者患有AA型系统性淀粉样变性。YO细胞的上清液以及重组人IL-6成功诱导非肿瘤性肝细胞产生血清淀粉样蛋白A（SAA）。我们的数据表明，肿瘤细胞产生的IL-6可能在该患者AA淀粉样变性的副肿瘤综合征中发挥了重要作用。
