[乌龟脾脏提取物CM-5组分的放射治疗效果]
[The radiotherapeutic effect of the CM-5 fraction of turtle spleen extract].
作者信息
Prus E K, Turdyev A A, Trifonov Iu A, Voloshin S V, Usmanov R B
出版信息
Radiats Biol Radioecol. 1994 Jan-Feb;34(1):138-42.
CM-5 fraction of tortoise spleen extract injected after irradiation in dose CD50/30 (540 R) raises a survival of mice to 73.4%. The number of endocolonies of spleen increases to 4.0 in experiment against 0.3 in control and the average life of experimental animals increases to 12.7 days against 8.8 in control. In vitro it has been found a considerable increase of RNA-synthetic activity of bone marrow cells stimulated by CM-5 fraction in post-irradiation period. The dose alteration factor for CM-5 fraction is 1.46 according to CD50/30 standard at survival test.
照射后以CD50/30（540伦琴）剂量注射乌龟脾脏提取物的CM - 5组分，可使小鼠存活率提高至73.4%。实验中脾脏内集落数增至4.0，而对照组为0.3；实验动物的平均寿命增至12.7天，而对照组为8.8天。在体外研究发现，照射后CM - 5组分刺激的骨髓细胞RNA合成活性显著增加。在存活试验中，根据CD50/30标准，CM - 5组分的剂量改变系数为1.46。
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