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[中亚陆龟血细胞提取物的血液和免疫刺激作用]

[Hemo- and immunostimulating effect of an extract from blood cells of the Central Asian tortoise].

作者信息

Turd'iev A A, Aleksandrov V V, Usmanov R B, Batyrbekov A A, Ivanov V I, Filiutovich O S, Tagaĭalieva N A

机构信息

Institute of Biochemistry, Academy of Sciences Republic of Uzbekistan, Tashkent.

出版信息

Radiats Biol Radioecol. 1998 Mar-Apr;38(2):207-14.

PMID:9633623
Abstract

Radiotherapeutic efficacious of the compounds from major organs and tissues of Central Asian tortoise--the animal known for its unique radioresistance, has been checked up. Along with the so well-known compounds as the plasma ones, tortoise spleen extracts (TSE) and the ones from the liver of adult animals and embryos, extracts from kidneys and muscles have been shown to increase the survivability rate of irradiated rats and mice. The compound, that called "Tortezin" shows the highest blood cell cytosol effect. The specific activity and the output are 4 and 12 times higher, than the ones of TSE, respectively. Dose increase factor (DIF) reaches as far as 1.41. The compound possesses considerable immunostimulating activity. The detailed physico-chemical characteristics of the compound, quite sufficient for its identification has been made.

摘要

对以其独特的抗辐射能力而闻名的中亚陆龟主要器官和组织中的化合物进行了放射治疗效果检查。除了众所周知的血浆化合物外,乌龟脾脏提取物(TSE)以及成年动物和胚胎肝脏中的提取物、肾脏和肌肉提取物已被证明可提高受辐照大鼠和小鼠的存活率。一种名为“Tortezin”的化合物显示出最高的血细胞胞质溶胶效应。其比活性和产量分别比TSE高4倍和12倍。剂量增加因子(DIF)高达1.41。该化合物具有相当强的免疫刺激活性。已经确定了该化合物足够用于鉴定的详细物理化学特性。

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