Poverennyĭ A M, Riabukhin Iu S, Tsyb A F
Radiats Biol Radioecol. 1994 Jan-Feb;34(1):8-15.
Ideas about the thyroid gland diseases development in people suffering from the Chernobyl accident explaining the absence of straight dose dependence of pathologies raise from the irradiation were elaborated. It is supposed that the probable reason for a number of these pathologies can be the inadequate and inopportune preventive iodine administration. It is known that significant amount of iodine being incorporated in children or persons with compromised thyroid gland could lead to a number of pathological changes, primarily to autoimmune thyroiditis which is a reason of other consequent pathologies of this organ. The principal mechanism of the process can be presented as following: iodine transformation (oxidation) in the thyroid gland accompanies with the generation of considerable quantities of various radicals imitating the radiation damage. This hypothesis allows to consider the children suffered from the Chernobyl accident with autoimmune thyroiditis as belonging to the group of risk as the literary data testify that the presence of autoimmune thyroiditis rises 75 time the risk of malignant lympho-proliferated diseases appearance. A simple immunological method of autoimmune thyroiditis diagnostics was developed which informativity is comparable with the method of ultrasound diagnostics. Serial production (the antibodies to microsomal fraction of thyroid gland) was organized. This method can be used in screening investigations.
关于切尔诺贝利事故受害者甲状腺疾病发展的观点已经形成，这些观点解释了疾病与辐射之间不存在直接剂量依赖关系的原因。据推测，许多此类疾病的可能原因是预防性碘摄入不足和时机不当。众所周知，大量碘进入儿童或甲状腺功能受损者体内可能导致多种病理变化，主要是自身免疫性甲状腺炎，而这是该器官其他后续疾病的一个原因。该过程的主要机制可描述如下：甲状腺内碘的转化（氧化）伴随着大量各种自由基的产生，这些自由基模拟了辐射损伤。这一假设使得将患有自身免疫性甲状腺炎的切尔诺贝利事故受害者视为高危人群成为可能，因为文献数据表明，自身免疫性甲状腺炎的存在会使恶性淋巴增殖性疾病出现的风险增加75倍。一种简单的自身免疫性甲状腺炎诊断免疫学方法已经开发出来，其信息性与超声诊断方法相当。组织了批量生产（针对甲状腺微粒体部分的抗体）。这种方法可用于筛查调查。
