奈替米星治疗实验性铜绿假单胞菌角膜炎

Nebcin in the treatment of experimental Pseudomonas keratitis.

作者信息

Belfort R, Smolin G, Okumoto M, Kim H B

出版信息

Br J Ophthalmol. 1975 Dec;59(12):725-9. doi: 10.1136/bjo.59.12.725.

DOI:10.1136/bjo.59.12.725

PMID:814918

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1017443/

Abstract

When the ocular toxicity and the in vivo and in vitro effects of gentamicin, Nebcin, and saline solution were compared in experimentally induced Pseudomonas keratitis in rabbits, both antibiotics showed the same toxicity for the rabbits' conjunctival tissues. But Nebcin showed better in vitro and in vivo results than gentamicin, and the clinical effect was confirmed by culture study: significant numbers of organisms were recovered from the corneas of the gentamicin-treated rabbits but none from the corneas of the Nebcin-treated rabbits.

摘要

当在实验诱导的兔铜绿假单胞菌角膜炎中比较庆大霉素、奈替米星（Nebcin）和盐溶液的眼毒性以及体内和体外作用时，两种抗生素对兔结膜组织显示出相同的毒性。但奈替米星在体外和体内的效果均优于庆大霉素，并且培养研究证实了其临床效果：从庆大霉素治疗组兔的角膜中可培养出大量细菌，而奈替米星治疗组兔的角膜中未培养出细菌。