Pryme I F, Pusztai A J, Bardocz S
Department of Biochemistry and Molecular Biology, University of Bergen, Norway.
Cancer Lett. 1994 Jan 30;76(2-3):133-7. doi: 10.1016/0304-3835(94)90389-1.
Mice injected intraperitoneally with Krebs II cells and then fed on a diet containing the lectin phytohaemagglutinin (PHA) developed ascites tumours more slowly than mice fed on a control diet. After an 8-day period following injection the number of cells recovered from mice maintained on the PHA diet was half that from those fed the control diet. A switch of diet from control to PHA on day 4 after injection resulted in a large decrease in number of tumour cells recovered. Mice injected s.c. also developed tumours at later times when fed on the PHA diet. A quantitative of ribosomes in polysome-containing fractions showed no major differences in protein synthesis in control mice and those fed the PHA diet.
经腹腔注射克雷布斯II细胞，然后喂食含有凝集素植物血凝素（PHA）的饮食的小鼠，与喂食对照饮食的小鼠相比，腹水肿瘤的发展更为缓慢。注射后8天，喂食PHA饮食的小鼠回收的细胞数量是喂食对照饮食的小鼠的一半。注射后第4天从对照饮食改为PHA饮食导致回收的肿瘤细胞数量大幅减少。皮下注射的小鼠在喂食PHA饮食时也在较晚时间出现肿瘤。对含多核糖体部分中的核糖体进行定量分析表明，对照小鼠和喂食PHA饮食的小鼠在蛋白质合成方面没有重大差异。
