Wylie I G, Afshar F, Koeze T H
Br J Radiol. 1975 Dec;48(576):1007-12. doi: 10.1259/0007-1285-48-576-1007.
An investigation was made of the use of a new water-soluble contrast material (metrizamide) for posterior-fossa radiography in the baboon. The experiments showed that the concentration of metrizamide needed to produce adequate radiographs from sub-occipital injections into the posterior fossa always produced generalized seizures. Intraventricular injection produced excellent radiographs from metrizamide concentrations, which did not result in either clinical or EEG seizure activity. Seizures, when they occurred, were easily controlled with pentobarbitone and phenytoin. In all the experiments, ECG changes were found, which disappeared after some hours.
对一种新型水溶性造影剂（甲泛葡胺）用于狒狒后颅窝造影的情况进行了研究。实验表明，从枕下注射到后颅窝以获得足够的X线片所需的甲泛葡胺浓度总是会引发全身性癫痫发作。脑室内注射甲泛葡胺后能获得出色的X线片，且该浓度不会导致临床或脑电图癫痫活动。癫痫发作时，用戊巴比妥和苯妥英很容易控制。在所有实验中均发现了心电图变化，这些变化在数小时后消失。
