Gonsette R E, Brucher J M
Neuroradiology. 1977 Aug 25;14(1):27-30. doi: 10.1007/BF00399884.
Experiments conducted on rabbits confirmed that chlorpromazine potentiates the weak epileptogenic action of Amipaque (metrizamide). Chlorpromazine withdrawal for a period of 48 h suppresses this potentiating effect in the rabbit. Neuroleptic drugs should therefore be avoided in patients examined with Amipaque. In patients under chronic treatment, neuroleptics ought to be discontinued at least 48 h before examination with Amipaque. With the doses and methods used in the present study, diazepam was not as effective as phenobarbital in preventing epilepsy produced by Amipaque. When premidication is needed or when convulsions occur after Amipaque examinations, combined diazepam and phenobarbital therapy ought to be instituted in order to achieve the best control of epileptic reactions.
对兔子进行的实验证实，氯丙嗪可增强阿米培克（甲泛葡胺）微弱的致癫痫作用。氯丙嗪停药48小时可抑制兔子的这种增强作用。因此，在用阿米培克检查的患者中应避免使用抗精神病药物。对于接受慢性治疗的患者，在使用阿米培克检查前至少48小时应停用抗精神病药物。就本研究中使用的剂量和方法而言，地西泮在预防阿米培克引发的癫痫方面不如苯巴比妥有效。当需要术前用药或在阿米培克检查后发生惊厥时，应采用地西泮和苯巴比妥联合治疗，以实现对癫痫反应的最佳控制。
