6(1),6n-二-O-(叔丁基二甲基甲硅烷基)-环麦芽糊精八糖的制备
Preparation of 6(1),6n-di-O-(tert-butyldimethylsilyl)-cyclomalto-octaoses.
作者信息
Tanimoto T, Sakaki T, Iwanaga T, Koizumi K
机构信息
Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan.
出版信息
Chem Pharm Bull (Tokyo). 1994 Feb;42(2):385-7. doi: 10.1248/cpb.42.385.
Four positional isomers of 6(1),6n-di-O-(tert-butyldimethylsilyl)- cyclomalto-octaose (n = 2-5) were prepared by reaction of cyclomalto-octaose (1, cG8) with tert-butyldimethylsilyl chloride in pyridine, and were isolated by high-performance liquid chromatography. The regiochemical determination of those positional isomers was performed by comparison with authentic compounds, prepared from 6(1),6n-di-O-trityl-cG8s (n = 2-5).
通过环麦芽糊精（1，cG8）与叔丁基二甲基氯硅烷在吡啶中反应制备了6(1),6n-二-O-(叔丁基二甲基硅基)-环麦芽八糖（n = 2 - 5）的四种位置异构体，并通过高效液相色谱法进行分离。通过与由6(1),6n-二-O-三苯甲基-cG8s（n = 2 - 5）制备的标准化合物进行比较，对这些位置异构体进行区域化学测定。
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