Siatra-Papastaikoudi T, Papadaki-Valiraki A, Tsantili-Kakoulidou A, Tzouvelekis L, Mentis A
Department of Pharmacy, University of Athens, Greece.
Chem Pharm Bull (Tokyo). 1994 Feb;42(2):392-4. doi: 10.1248/cpb.42.392.
The synthesis of some novel quaternary ammonium salts, derivatives of 15-phenyl-decapentanoic acid, is described. Their lipophilicity was estimated applying the Hansch-Leo fragmental procedure and measured by means of reversed phase thin layer chromatography. All compounds were tested for their antibacterial activity against Gram positive and gram negative microorganisms. The less lipophilic compounds showed weak activity, mainly against gram positive microorganisms.
描述了一些新型季铵盐（15-苯基-癸戊酸的衍生物）的合成。采用Hansch-Leo碎片法评估其亲脂性，并通过反相薄层色谱法进行测定。对所有化合物针对革兰氏阳性和革兰氏阴性微生物的抗菌活性进行了测试。亲脂性较低的化合物表现出较弱的活性，主要针对革兰氏阳性微生物。
