Hiramatsu Y, Okabe S
Department of Applied Pharmacology, Kyoto Pharmaceutical University, Japan.
Dig Dis Sci. 1994 Apr;39(4):689-97. doi: 10.1007/BF02087409.
We examined the effect of histamine administered intraduodenally as well as subcutaneously or intravenously on the gastric acid secretion in rats and guinea pigs, using a newly devised cannula. Intraduodenally administered histamine dihydrochloride caused a significant dose-dependent increase in the gastric acid secretion in rats. The maximal acid secretion, which corresponded to that after subcutaneous (20 mg/kg) or intravenous (10 mg/kg/hr) administration of histamine, was observed within 30 min after intraduodenal administration (40 mg/kg). The plasma concentrations of histamine determined 30 min after intraduodenal, subcutaneous, and intravenous administration of histamine were nearly the same. Pretreatment with aminoguanidine sulfate (diamine oxidase inhibitor) at 30 mg/kg significantly increased the gastric acid secretion caused by intraduodenal histamine. The gastric acid secretion stimulated by intraduodenal histamine was significantly inhibited by cimetidine, pirenzepine, and omeprazole, but remained unchanged with tripelennamine. Intraduodenal histamine (20 mg/kg) also maximally stimulated the gastric acid secretion in guinea pigs. The response was comparable to that with subcutaneous histamine (1 mg/kg). We conclude that intraduodenal histamine has the ability to stimulate gastric acid secretion in both rats and guinea pigs.
我们使用一种新设计的插管，研究了十二指肠内、皮下或静脉注射组胺对大鼠和豚鼠胃酸分泌的影响。十二指肠内注射盐酸组胺可使大鼠胃酸分泌呈显著的剂量依赖性增加。在十二指肠内注射（40mg/kg）后30分钟内观察到最大胃酸分泌，这与皮下（20mg/kg）或静脉注射（10mg/kg/小时）组胺后的最大胃酸分泌相当。在十二指肠内、皮下和静脉注射组胺30分钟后测定的血浆组胺浓度几乎相同。以30mg/kg的硫酸氨基胍（二胺氧化酶抑制剂）预处理可显著增加十二指肠内组胺引起的胃酸分泌。十二指肠内组胺刺激的胃酸分泌受到西咪替丁、哌仑西平、奥美拉唑的显著抑制，但曲吡那敏对其无影响。十二指肠内组胺（20mg/kg）也能最大程度地刺激豚鼠胃酸分泌。该反应与皮下注射组胺（1mg/kg）的反应相当。我们得出结论，十二指肠内组胺具有刺激大鼠和豚鼠胃酸分泌的能力。
