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[肠道菌群和饮食对大鼠肠道胆汁盐池及粪便胆汁盐排泄的影响]

[Effect of intestinal flora and diet on rat intestinal pool and fecal excretion of bile salts].

作者信息

Sacquet M E, Méjean C, Leprince C, Riottot M M

出版信息

C R Acad Hebd Seances Acad Sci D. 1975 Nov 3;281(18):1337-9.

PMID:815022
Abstract

Comparative studies between groups of rats which differ by the microbial flora of their gastrointestinal tract, the weight of their caecum and the diet on which they are fed allow the following conclusions: 1. Caecal enlargement is, on the one hand, mainly responsible for the increased intestinal pool of bile salts in the intestine of germ-free rats and on the other has little action on the decrease of their fecal excretion. 2. Other than for intestinal flora, diet modifies intestinal pool and fecal excretion of bile salts. Fecal excretion mainly depends on diet cholesterol content. Intestinal pool size mainly depends on dietary factors which are different from cholesterol.

摘要

对胃肠道微生物菌群、盲肠重量及所喂食饮食不同的大鼠组进行比较研究,可得出以下结论:1. 一方面,盲肠增大是无菌大鼠肠道中胆汁盐肠池增加的主要原因,另一方面,对其粪便排泄减少作用不大。2. 除肠道菌群外,饮食会改变胆汁盐的肠池和粪便排泄。粪便排泄主要取决于饮食中的胆固醇含量。肠池大小主要取决于与胆固醇不同的饮食因素。

相似文献

1
[Effect of intestinal flora and diet on rat intestinal pool and fecal excretion of bile salts].[肠道菌群和饮食对大鼠肠道胆汁盐池及粪便胆汁盐排泄的影响]
C R Acad Hebd Seances Acad Sci D. 1975 Nov 3;281(18):1337-9.
2
[Effect of diet and of the microbial flora of the digestive tract on the intestinal pool and fecal excretion of bile acids in the rat: a comparative study in axenic, ghotoxenic and holoxenic rats].[饮食及消化道微生物群对大鼠胆汁酸肠池及粪便排泄的影响:无菌、悉生和普通大鼠的比较研究]
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Intestinal and fecal sterols in germfree and conventional rats. Bile acids and steroids 172.无菌和普通大鼠体内的肠道及粪便甾醇。胆汁酸与类固醇172。
Acta Chem Scand. 1966;20(7):1827-35. doi: 10.3891/acta.chem.scand.20-1827.
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[Action of microbial flora of the digestive tract on the metabolism of bile acids in the rat (author's transl)].[大鼠消化道微生物区系对胆汁酸代谢的作用(作者译)]
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Dietary fiber and cholesterol and bile acid metabolism in axenic (germfree) and holoxenic (conventional) rats. III. Effect of non-sterilized pectin.无菌(悉生)和普通(常规)大鼠的膳食纤维与胆固醇及胆汁酸代谢。III. 未灭菌果胶的作用
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The hypocholesterolemic effect of high amylose cornstarch in rats is mediated by an enlarged bile acid pool and increased fecal bile acid excretion, not by cecal fermented products.高直链玉米淀粉对大鼠的降胆固醇作用是由胆汁酸池扩大和粪便胆汁酸排泄增加介导的,而非由盲肠发酵产物介导。
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Gastroenterology. 1988 Feb;94(2):494-502. doi: 10.1016/0016-5085(88)90443-x.
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Fecal losses of sterols and bile acids induced by feeding rats guar gum are due to greater pool size and liver bile acid secretion.给大鼠喂食瓜尔胶所引起的粪便中固醇和胆汁酸的损失,是由于更大的池大小和肝脏胆汁酸分泌。
J Nutr. 1997 Jun;127(6):1068-76. doi: 10.1093/jn/127.6.1068.
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Influence of microbial bile salt desulfation upon the fecal excretion of bile salts in gnotobiotic rats.无菌大鼠中微生物胆盐脱硫作用对胆盐粪便排泄的影响。
J Steroid Biochem. 1985 Apr;22(4):547-54. doi: 10.1016/0022-4731(85)90176-1.
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The 'normalization' of germ-free rabbits with host-specific caecal microflora.用宿主特异性盲肠微生物群对无菌兔进行“定植”。
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