Roithmann S, Pique C, Le Cesne A, Delamarre L, Pham D, Tursz T, Dokhélar M C
CNRS Unité de Recherche Associée 1156, Institut Gustave Roussy, Villejuif, France.
J Virol. 1994 May;68(5):3448-51. doi: 10.1128/JVI.68.5.3448-3451.1994.
The X region of the human T-cell leukemia virus type I contains the second coding exon of the tax and rex regulatory proteins (open reading frame IV [ORF IV] and ORF III, respectively), as well as coding regions for more recently described proteins, p30II (or the tof protein) and p13II in ORF II and the putative rof protein and p12I in ORF I. Deletions and transcomplementation experiments showed that expression of the envelope, as well as that of the tax and rex proteins, was independent of the proteins encoded in the ORF I/ORF II region. Furthermore, p30II and p12I proteins could not replace the rex protein in a rex-dependent envelope or Gag protein expression system.
人类I型T细胞白血病病毒的X区域包含tax和rex调节蛋白的第二个编码外显子（分别为开放阅读框IV [ORF IV]和ORF III），以及最近描述的蛋白质的编码区域，即ORF II中的p30II（或tof蛋白）和p13II，以及ORF I中的推定rof蛋白和p12I。缺失和反式互补实验表明，包膜蛋白以及tax和rex蛋白的表达独立于ORF I/ORF II区域编码的蛋白质。此外，在依赖rex的包膜或Gag蛋白表达系统中，p30II和p12I蛋白不能替代rex蛋白。
