Nguyen N X, Küchle M, Naumann G O
Augenklinik mit Poliklinik, Universität Erlangen-Nürnberg.
Klin Monbl Augenheilkd. 1994 Jan;204(1):33-6. doi: 10.1055/s-2008-1035499.
The Laser Flare-Cell Meter allows noninvasive quantitative measurement of aqueous flare in human eyes. In this study we analysed changes of aqueous flare in eyes with sympathetic ophthalmia under immunosuppressive treatment.
Two men (54- and 59-year-old) with sympathetic ophthalmia (histological examination of the enucleated eyes confirmed the clinical diagnosis) were examined regularly with the Laser Flare-Cell Meter (Kowa). According to the flare values the dose of immunosuppressive treatment with cyclosporin A and prednisolone was gradually titrated.
Under immunosuppressive treatment flare values of patient 1 normalized within 21 months. The dose of immunosuppressive treatment was carefully reduced according to flare values. Patient 2 showed very high flare values before treatment, which decreased to flare values of 20 flare counts/ms within 5 months of treatment with cyclosporin A and prednisolone. Both patients stopped immunosuppressive treatment because of systemic side-effects. Thereafter flare values increased acutely and a recurrence of sympathetic ophthalmia was observed in both patients. Under renewed immunosuppressive treatment aqueous flare values decreased again.
Measurement of aqueous flare with the LFCM appears to be an effective tool for follow-up examinations, and especially for titrating of immunosuppressive treatment in eyes with manifest sympathetic ophthalmia.
激光闪光细胞仪可对人眼房水闪光进行无创定量测量。在本研究中，我们分析了免疫抑制治疗下交感性眼炎患者房水闪光的变化。
两名患有交感性眼炎的男性（分别为54岁和59岁，摘除眼球的组织学检查证实了临床诊断）定期使用激光闪光细胞仪（柯瓦）进行检查。根据闪光值逐步调整环孢素A和泼尼松龙免疫抑制治疗的剂量。
在免疫抑制治疗下，患者1的闪光值在21个月内恢复正常。根据闪光值谨慎降低免疫抑制治疗的剂量。患者2在治疗前闪光值非常高，在用环孢素A和泼尼松龙治疗5个月内降至20个闪光计数/毫秒的闪光值。两名患者均因全身副作用停止免疫抑制治疗。此后，闪光值急剧升高，两名患者均出现交感性眼炎复发。再次进行免疫抑制治疗后，房水闪光值再次降低。
使用激光闪光细胞仪测量房水闪光似乎是随访检查的有效工具，尤其是在明显的交感性眼炎患者中用于调整免疫抑制治疗。
