Witty L A, Tapson V F, Piantadosi C A
Division of Allergy, Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710.
Medicine (Baltimore). 1994 Mar;73(2):103-9. doi: 10.1097/00005792-199403000-00003.
Pulmonary alveolar proteinosis (PAP) is a rare disorder characterized by accumulation of proteinaceous material in the alveoli of affected individuals. Pulmonary infections appear to develop with increased frequency in these patients. The increased rate of infection has been attributed to immunologic aberrations, such as impaired alveolar macrophage function, particularly when uncommon pathogens are involved. Among those pathogens, Nocardia asteroides and Mycobacterium tuberculosis have appeared most often in case reports in the literature. Mycobacterium avium-intracellulare (MAI) has rarely been isolated in these patients. We report an unusually high incidence of MAI isolation from lavage fluid in 8 of 19 consecutive patients who underwent therapeutic lung lavage for relief of symptomatic PAP, and summarize the available literature on isolation of potential respiratory pathogens in PAP.
肺泡蛋白沉积症（PAP）是一种罕见的疾病，其特征是患病个体的肺泡中积聚蛋白质物质。这些患者肺部感染的发生率似乎更高。感染率的增加归因于免疫异常，如肺泡巨噬细胞功能受损，特别是在涉及不常见病原体时。在这些病原体中，星形诺卡菌和结核分枝杆菌在文献中的病例报告中出现得最为频繁。鸟分枝杆菌-胞内分枝杆菌（MAI）在这些患者中很少分离出来。我们报告了19例因缓解症状性PAP而接受治疗性肺灌洗的连续患者中有8例从灌洗液中分离出MAI的异常高发生率，并总结了关于PAP中潜在呼吸道病原体分离的现有文献。
