自身免疫性肺泡蛋白沉积症因合并非结核分枝杆菌感染单独治疗而改善的病情加重：一例报告
Exacerbation of autoimmune pulmonary alveolar proteinosis that improved with lone treatment of complicating nontuberculous mycobacterial infection: A case report.
作者信息
Shiohira Shunya, Sakayori Masashi, Yoshioka Keiichiro, Kasai Hajime, Hirama Ryutaro, Abe Mitsuhiro, Nishimura Hiroki, Suzuki Takuji
机构信息
Department of Medicine, School of Medicine, Chiba University, Chiba, 260-8670 Japan.
Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.
出版信息
Respir Med Case Rep. 2021 Sep 27;34:101521. doi: 10.1016/j.rmcr.2021.101521. eCollection 2021.
Herein, we present the case of a 63-year-old man with autoimmune pulmonary alveolar proteinosis (APAP) complicated by complex (MAC) infection. APAP was diagnosed based on serum anti-granulocyte-macrophage colony-stimulating factor antibody, bronchoalveolar lavage fluid (BALF) findings, and transbronchial lung biopsy. Nodular shadows with cavities were visible on chest CT images, and was identified by BALF culture. Rifampicin, ethambutol, and clarithromycin were administered, and 4 months later, the nodular shadows of MAC had disappeared, and APAP was remarkably improved. Thus, in cases of APAP exacerbation complicated with infections, such as MAC, control of the infections may improve APAP.
在此，我们报告一例63岁男性自身免疫性肺泡蛋白沉积症（APAP）合并鸟分枝杆菌复合群（MAC）感染的病例。APAP是根据血清抗粒细胞-巨噬细胞集落刺激因子抗体、支气管肺泡灌洗液（BALF）检查结果及经支气管肺活检确诊的。胸部CT图像上可见有空洞的结节状阴影，通过BALF培养鉴定出MAC。给予利福平、乙胺丁醇和克拉霉素治疗，4个月后，MAC的结节状阴影消失，APAP明显改善。因此，在APAP加重合并MAC等感染的病例中，控制感染可能会改善APAP。
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