Sato J, Suzuki S, Iseki T, Kumazawa T
Department of Neural Regulation, Research Institute of Environmental Medicine, Nagoya University, Japan.
Neurosci Lett. 1993 Dec 24;164(1-2):225-8. doi: 10.1016/0304-3940(93)90897-t.
To probe the mechanisms underlying sympathetically maintained pain, the effects of lumbar sympathetic chain stimulation (SS) and close arterial injection of norepinephrine (NE) on cutaneous nociceptor activities were studied in adjuvant inflamed rats. Two to 28 weeks after adjuvant treatment, single nerve recordings of polymodal receptors from the saphenous nerve were performed. In treated rats but not in controls, SS and NE were excitatory in 35-40% of units. Yohimbine and CH-38083 blocked NE excitation, but prazosin did not. Our data show that chronic inflammation initiates circumstances in which alpha 2-adrenoceptor-mediated sympathetic activity excites some nociceptors.
为探究交感神经维持性疼痛的潜在机制，我们在佐剂性炎症大鼠中研究了腰交感神经链刺激（SS）和动脉内注射去甲肾上腺素（NE）对皮肤伤害性感受器活动的影响。佐剂治疗后2至28周，对来自隐神经的多模式感受器进行单神经记录。在治疗组大鼠而非对照组中，SS和NE使35 - 40%的单位产生兴奋。育亨宾和CH - 38083可阻断NE的兴奋作用，但哌唑嗪则不能。我们的数据表明，慢性炎症引发了α2 - 肾上腺素能受体介导的交感神经活动兴奋某些伤害性感受器的情况。
