Reeves W H, Satoh M, Wang J, Chou C H, Ajmani A K
Department of Medicine, University of North Carolina, Chapel Hill.
Rheum Dis Clin North Am. 1994 Feb;20(1):1-28.
Pathogenic autoantibodies to DNA are frequently associated with autoantibodies to chromatin-associated proteins such as histones or the Ku (p70/p80) antigens. In view of the increasing evidence that autoantibody production is antigen-driven, and because DNA is packaged with proteins in the cell, we suggest that anti-DNA antibodies may arise in response to DNA-protein complexes rather than naked DNA. Recent studies of the specificities of autoantibodies directed against the components of nucleosomes and transcriptional complexes are consistent with this hypothesis. The possible clinical significance of immune recognition of various types of chromatin complexes in autoimmune disease is discussed.
针对DNA的致病性自身抗体常与针对染色质相关蛋白（如组蛋白或Ku（p70/p80）抗原）的自身抗体相关。鉴于越来越多的证据表明自身抗体的产生是由抗原驱动的，并且由于DNA在细胞中与蛋白质结合，我们认为抗DNA抗体可能是针对DNA-蛋白质复合物而非裸露的DNA产生的。最近针对核小体和转录复合物成分的自身抗体特异性研究与这一假设一致。本文讨论了自身免疫性疾病中各种染色质复合物免疫识别的可能临床意义。
