Mulder B, Tchuinkam T, Dechering K, Verhave J P, Carnevale P, Meuwissen J H, Robert V
University of Wageningen, Nijmegen, The Netherlands.
Trans R Soc Trop Med Hyg. 1994 Jan-Feb;88(1):121-5. doi: 10.1016/0035-9203(94)90534-7.
Experimental infections of anopheline mosquitoes were carried out with Plasmodium falciparum gametocytes from 65 naturally infected patients in Cameroon. A comparison was made between infections with blood containing autologous plasma and blood in which the plasma was replaced with plasma from a donor without previous malaria exposure. A lower infection rate was observed in 50 of 65 autologous plasma samples. Transmission was significantly blocked in 3 infections. This indicates that, in a population living in an area endemic for malaria, blood plasma factor(s) can reduce the transmission capacity of gametocyte carriers to mosquitoes.
使用来自喀麦隆65名自然感染患者的恶性疟原虫配子体对按蚊进行了实验性感染。对含有自体血浆的血液感染与血浆被未感染过疟疾的供体血浆替代的血液感染进行了比较。在65份自体血浆样本中的50份中观察到较低的感染率。在3次感染中传播被显著阻断。这表明，在疟疾流行地区的人群中，血浆因子可降低配子体携带者向蚊子的传播能力。
