Martin H, Maris P
CNEVA, Laboratoire des médicaments vétérinaires, La Haute-Marche, Javene.
Ann Pharm Fr. 1993;51(4):175-85.
We developed and validated a micromethod similar to the checkerboard method in antibiotherapy to study the efficiency of antiseptic and disinfectant molecules. The determination of the FBC index (Fractional Bactericidal Concentration) on 4 reference strains (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus hirae) for 4 associations (2-benzyl-4 chlorophenol--iodophor; cetrimide-iodophor, 2 benzyl-4 chlorophenol--formaldehyde; hexamidine--formaldehyde) revealed 2 synergistic associations and 2 antagonistic associations for one or more strains.
我们开发并验证了一种类似于抗菌疗法中棋盘法的微量方法，以研究防腐剂和消毒剂分子的功效。对4种组合（2-苄基-4-氯苯酚-碘伏；西曲溴铵-碘伏，2-苄基-4-氯苯酚-甲醛；己脒-甲醛）的4种参考菌株（大肠杆菌、铜绿假单胞菌、金黄色葡萄球菌、海氏肠球菌）进行FBC指数（杀菌分数浓度）测定，结果显示一种或多种菌株存在2种协同组合和2种拮抗组合。
