Shvets O L, Tsinzerling V A, Sorokina M N
Arkh Patol. 1993;55(5):12-6.
An analysis of 108 cases of children's death which occurred in 1981-1991 from hypertoxic meningococcal infection (MI) in St. Petersburg is presented. Serogroup B meningococcus as a causative agent was found in 44% of the cases. The role in the thanatogenesis of inflammatory and immune reactions, viral-bacterial associations was shown on the basis of detailed study of 47 cases. Hemorrhagic adrenal necrosis was diagnosed in 94.7% of the cases. Two clinicomorphological variants of the disease are distinguished: 1) variant with a moderate hemorrhagic eruption without pronounced kidney lesion, 2) variant with an abundant confluent rash and pronounced kidney lesions and choroid plexus immune lesions.
本文对1981年至1991年发生在圣彼得堡的108例儿童因剧毒脑膜炎球菌感染（MI）死亡的病例进行了分析。在44%的病例中发现B群脑膜炎球菌为病原体。在对47例病例进行详细研究的基础上，显示了炎症和免疫反应、病毒 - 细菌关联在死因形成中的作用。94.7%的病例诊断出出血性肾上腺坏死。该疾病有两种临床形态学变体：1）伴有中度出血性皮疹且无明显肾脏病变的变体；2）伴有大量融合性皮疹、明显肾脏病变和脉络丛免疫病变的变体。
