Khodasevich L S, Val'kov A V
Arkh Patol. 1997 Sep-Oct;59(5):22-7.
The kidneys of 30 children aged 1 month to 5 years who died of meningococcal infection were studied. Three variants of the kidney damage were distinguished on the basis of morphometric parameters. These variants corresponded to the stages of the infectious-toxic shock. The 1st variant observed in the reversible shock stages was characterized by arteriolar spasm and circulation shunts. The 2nd variant corresponded to initial manifestations of the disseminated vascular coagulation and was characterized by a combination of spasm and paralytic arteriola dilatation with a predominant thrombosis of the juxtamedullar glomeruli. The 3rd variant, the stage of the organ alterations, was followed by development of glomerular thrombotic microangiopathy with tubular epithelial necrosis in the proximal tubules this being the morphological counterpart of the hemolytico-uremic syndrome.
对30名1个月至5岁死于脑膜炎球菌感染的儿童的肾脏进行了研究。根据形态测量参数区分出三种肾脏损伤变体。这些变体与感染性中毒性休克的阶段相对应。在可逆性休克阶段观察到的第一种变体的特征是小动脉痉挛和循环分流。第二种变体对应于弥散性血管内凝血的初始表现，其特征是痉挛与麻痹性小动脉扩张相结合，伴有近髓肾小球的主要血栓形成。第三种变体即器官改变阶段，随后发展为肾小球血栓性微血管病，并伴有近端小管的肾小管上皮坏死，这是溶血尿毒症综合征的形态学对应表现。
