Dhawan J, Bray C L
Department of Cardiology, Wythenshawe Hospital, Manchester, UK.
Atherosclerosis. 1994 Jan;105(1):35-41. doi: 10.1016/0021-9150(94)90005-1.
In the present study the association between angiographically demonstrated coronary artery disease lipid subfractions and insulin in Caucasians, Asian migrants to the UK and Asians in India was studied. Patients having at least one angiographic lesion of more than 50% were recruited and angiograms scored by two independent observers, blindly. There were 87 Caucasian, 83 British Asian and 30 Indian Asian patients. Lipid subfractions measured were cholesterol, HDL cholesterol, triglyceride, apo A1, apo B, Lp(a). Estimation of glucose and insulin was carried out at fasting and after two hours of oral 75 g glucose. Asians were younger than Caucasians. They did not differ in their body mass index, systolic and diastolic blood pressure or cigarette consumption. In all three ethnic groups cholesterol, LDL cholesterol and apo B showed significant positive association. Insulin levels at fasting or post glucose challenge failed to show any association. Apo B may be an additional marker for coronary artery disease in the ethnic groups studied.
在本研究中，对高加索人、移民至英国的亚洲人和印度亚洲人的血管造影显示的冠状动脉疾病、脂质亚组分与胰岛素之间的关联进行了研究。招募了至少有一处血管造影病变超过50%的患者，并由两名独立观察者对血管造影进行盲法评分。共有87名高加索人、83名英国亚洲人和30名印度亚洲人患者。所测量的脂质亚组分包括胆固醇、高密度脂蛋白胆固醇、甘油三酯、载脂蛋白A1、载脂蛋白B、脂蛋白(a)。在空腹及口服75克葡萄糖两小时后进行血糖和胰岛素的测定。亚洲人比高加索人年轻。他们在体重指数、收缩压和舒张压或吸烟量方面没有差异。在所有三个种族群体中，胆固醇、低密度脂蛋白胆固醇和载脂蛋白B均呈显著正相关。空腹或葡萄糖激发后的胰岛素水平未显示出任何关联。载脂蛋白B可能是所研究种族群体中冠状动脉疾病的一个额外标志物。
