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人类朗格汉斯细胞上的FcεRI:寻找新功能的受体

Fc epsilon RI on human Langerhans cells: a receptor in search of new functions.

作者信息

Bieber T

机构信息

Dept of Dermatology, Ludwig-Maximilians University, Munich, Germany.

出版信息

Immunol Today. 1994 Feb;15(2):52-3. doi: 10.1016/0167-5699(94)90132-5.

DOI:10.1016/0167-5699(94)90132-5
PMID:8155262
Abstract

The recent demonstration that the high-affinity receptor for IgE, Fc epsilon RI, is expressed on human Langerhans cells casts a new perspective on the function of this receptor. This observation also provides a new direction for further investigation into the pathophysiological relevance of Langerhans cells and other antigen-presenting cells in the development of atopic diseases.

摘要

最近的研究表明,IgE的高亲和力受体FcεRI在人朗格汉斯细胞上表达,这为该受体的功能提供了新的视角。这一观察结果也为进一步研究朗格汉斯细胞和其他抗原呈递细胞在特应性疾病发展中的病理生理相关性提供了新的方向。

相似文献

1
Fc epsilon RI on human Langerhans cells: a receptor in search of new functions.人类朗格汉斯细胞上的FcεRI:寻找新功能的受体
Immunol Today. 1994 Feb;15(2):52-3. doi: 10.1016/0167-5699(94)90132-5.
2
Fc epsilon RI on human epidermal Langerhans cells: an old receptor with new structure and functions.
Int Arch Allergy Immunol. 1997 May-Jul;113(1-3):30-4. doi: 10.1159/000237500.
3
[IgE receptors in Langerhans cells. A link between the environment and the immune system?].[朗格汉斯细胞中的IgE受体。环境与免疫系统之间的联系?]
Hautarzt. 1992 Dec;43(12):753-62.
4
Surface expression of Fc epsilon RI on Langerhans' cells of clinically uninvolved skin is associated with disease activity in atopic dermatitis, allergic asthma, and rhinitis.FcεRI在临床未受累皮肤的朗格汉斯细胞上的表面表达与特应性皮炎、过敏性哮喘和鼻炎的疾病活动相关。
J Allergy Clin Immunol. 2003 Aug;112(2):411-9. doi: 10.1067/mai.2003.1626.
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Immunoglobulin E-binding structures on antigen-presenting cells present in skin and blood.皮肤和血液中存在的抗原呈递细胞上的免疫球蛋白E结合结构。
J Invest Dermatol. 1995 May;104(5):707-10. doi: 10.1111/1523-1747.ep12606958.
6
A review on Fc epsilon RI on human epidermal Langerhans cells.关于人类表皮朗格汉斯细胞上FcεRI的综述。
Int Arch Allergy Immunol. 1994;104 Suppl 1(1):63-4. doi: 10.1159/000236756.
7
Human epidermal Langerhans cells express the high affinity receptor for immunoglobulin E (Fc epsilon RI).人表皮朗格汉斯细胞表达免疫球蛋白E(FcεRI)的高亲和力受体。
J Exp Med. 1992 May 1;175(5):1285-90. doi: 10.1084/jem.175.5.1285.
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Activation of human epidermal Langerhans cells by engagement of the high affinity receptor for IgE, Fc epsilon RI.通过IgE高亲和力受体FcεRI的结合激活人表皮朗格汉斯细胞。
J Immunol. 1995 Dec 1;155(11):5184-9.
9
Fc epsilon RI mediates IgE binding to human epidermal Langerhans cells.FcεRI介导IgE与人表皮朗格汉斯细胞的结合。
J Invest Dermatol. 1992 Nov;99(5):30S-32S. doi: 10.1111/1523-1747.ep12668293.
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Peripheral blood dendritic cells express Fc epsilon RI as a complex composed of Fc epsilon RI alpha- and Fc epsilon RI gamma-chains and can use this receptor for IgE-mediated allergen presentation.外周血树突状细胞表达由FcεRIα链和FcεRIγ链组成的复合物形式的FcεRI,并可利用该受体进行IgE介导的过敏原呈递。
J Immunol. 1996 Jul 15;157(2):607-16.

引用本文的文献

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Immunoglobulin e-mediated allergy plays a role in atopic eczema as shown in the atopy patch test.免疫球蛋白 E 介导的过敏反应在特应性皮炎中起作用,特应性皮炎斑贴试验可证实这一点。
World Allergy Organ J. 2008 Mar;1(3):51-6. doi: 10.1097/WOX.0b013e3181661472.
2
Allergen-specific immunotherapy in atopic eczema.变应原特异性免疫疗法在特应性皮炎中的应用。
Curr Allergy Asthma Rep. 2011 Aug;11(4):277-83. doi: 10.1007/s11882-011-0194-7.
3
Cotranslational endoplasmic reticulum assembly of FcepsilonRI controls the formation of functional IgE-binding receptors.
FcepsilonRI的共翻译内质网组装控制功能性IgE结合受体的形成。
J Exp Med. 2005 Jan 17;201(2):267-77. doi: 10.1084/jem.20041384. Epub 2005 Jan 10.
4
[Atopic patch test. Atopic eczema and allergy].[特应性斑贴试验。特应性皮炎与过敏]
Hautarzt. 2003 Oct;54(10):930-6. doi: 10.1007/s00105-003-0601-7.
5
Interleukin-7 in the skin of Schistosoma mansoni-infected mice is associated with a decrease in interferon-gamma production and leads to an aggravation of the disease.曼氏血吸虫感染小鼠皮肤中的白细胞介素-7与γ干扰素产生减少有关,并导致疾病加重。
Immunology. 1997 May;91(1):35-44. doi: 10.1046/j.1365-2567.1997.00229.x.
6
High affinity IgE receptor (Fc epsilon RI) expression on eosinophils infiltrating the lesions and mite patch tested sites in atopic dermatitis.特应性皮炎患者皮损及螨斑试验部位浸润嗜酸性粒细胞上高亲和力IgE受体(FcεRI)的表达
Arch Dermatol Res. 1995;287(8):712-7. doi: 10.1007/BF01105794.
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Role of epidermal Langerhans' cells in the induction of protective immunity to Schistosoma mansoni in guinea-pigs.
Immunology. 1995 Feb;84(2):233-40.