de Souza Silva M, Guimarães F S, Graeff F G, Tomaz C
Laboratory of Psychobiology and Center for Neuroscience and Behavior, University of São Paulo, Ribeirão Preto, Brasil.
Behav Brain Res. 1993 Dec 31;59(1-2):141-5. doi: 10.1016/0166-4328(93)90160-r.
This experiment compares the effects of microinjections into the basolateral amygdala nucleus of diazepam (DZP) and a new 5-HT3 receptor antagonist, BRL 46470A, on acquisition and retention of an inhibitory avoidance tasks by rats. The animals were microinjected with DZP or BRL 46470A between 10 and 15 min before the learning trial. Retention testing 48 h later showed impaired retention in animals injected with DZP but not with BRL 46470A. These results show that BRL 46470A, a compound suggested to have anxiolytic effects does not induce amnesia. This evidence for a possible dissociation between anxiety-reducing and memory-disrupting effects of a drug has implications, for one, for the understanding of the neuronal substrates mediating these effects, and secondly, for the search for anxiolytic agents devoid of undesirable side effects on memory processes.
本实验比较了向大鼠基底外侧杏仁核微量注射地西泮（DZP）和一种新型5-羟色胺3（5-HT3）受体拮抗剂BRL 46470A对抑制性回避任务的习得和保持的影响。在学习试验前10至15分钟，给动物微量注射DZP或BRL 46470A。48小时后的保持测试显示，注射DZP的动物保持能力受损，而注射BRL 46470A的动物则未受损。这些结果表明，被认为具有抗焦虑作用的化合物BRL 46470A不会诱发失忆。药物的抗焦虑作用和记忆破坏作用可能分离的这一证据，一方面有助于理解介导这些作用的神经基质，另一方面有助于寻找对记忆过程无不良副作用的抗焦虑药物。
