Silva M A, Tomaz C
Laboratory of Psychobiology, University of São Paulo, Ribeirão Prêto, Brazil.
Neuropsychobiology. 1995;32(1):31-6. doi: 10.1159/000119209.
Recent findings indicate that the memory-impairing effects of benzodiazepines may preferentially involve the basolateral nucleus of the amygdala. To test this hypothesis we examined the effects on pretrial injection of diazepam into the central as compared to the lateral/basolateral amygdaloid nuclei on memory for a conditioned avoidance response. Rats were implanted bilaterally with cannulae directed to either the central or lateral/basolateral amygdaloid nuclei. Five to 7 days later they were trained on a multitrial inhibitory avoidance (step-down) task to criterion and tested 48 h later. Fifteen minutes before training they were given an injection of either vehicle or diazepam (0.7 or 1.4 nmol) into the central or lateral/basolateral nuclei. Administration of diazepam into the lateral/basolateral nuclei but not the central nucleus induced anterograde amnesia. These results add to the body of data linking the GABA-benzodiazepine system of the lateral/basolateral nuclei to the amnestic effects induced by peripheral as well as central administration of benzodiazepines.
最近的研究结果表明，苯二氮䓬类药物损害记忆的作用可能主要涉及杏仁核的基底外侧核。为了验证这一假设，我们研究了在条件性回避反应记忆方面，向杏仁核中央核注射地西泮与向外侧/基底外侧核注射地西泮的预处理效果。给大鼠双侧植入分别指向杏仁核中央核或外侧/基底外侧核的套管。5至7天后，对它们进行多次试验性抑制性回避（跳下）任务训练，直至达到标准，并在48小时后进行测试。在训练前15分钟，向中央核或外侧/基底外侧核注射溶剂或地西泮（0.7或1.4纳摩尔）。向外侧/基底外侧核而非中央核注射地西泮会导致顺行性遗忘。这些结果进一步补充了相关数据，将外侧/基底外侧核的GABA-苯二氮䓬系统与外周及中枢给予苯二氮䓬类药物所诱导的遗忘效应联系起来。
