新型5-羟色胺3（5-HT3）受体拮抗剂BRL 46470A和劳拉西泮对心理测量性能及脑电图的影响。
The effects of BRL 46470A, a novel 5-HT3 receptor antagonist, and lorazepam on psychometric performance and the EEG.
作者信息
Link C G, Leigh T J, Dennison J K
机构信息
Clinical Pharmacology Unit, SmithKline Beecham Pharmaceuticals, Harlow, Essex.
出版信息
Br J Clin Pharmacol. 1993 Apr;35(4):395-9. doi: 10.1111/j.1365-2125.1993.tb04156.x.
Abstract
- The effects of single doses of a novel 5-HT3 receptor antagonist, BRL 46470A (0.1 microgram, 0.01 mg, 1 mg or 50 mg) and lorazepam (2.5 mg) on psychometric performance and the EEG were investigated in a randomised, double-blind, crossover, placebo controlled study of 16 healthy male volunteers. 2. There was strong evidence that lorazepam had a marked effect on the EEG, increasing power in the 1 Hz to 7 Hz and 13 Hz to 20 Hz wavebands, whilst reducing power in the 8 Hz to 12 Hz waveband. Lorazepam also produced an impairment of daytime function as assessed by psychometric performance and subjective measures. 3. In contrast, there was little evidence to suggest that BRL 46470A had any effect on the EEG or that it impaired daytime function.
摘要
- 在一项针对16名健康男性志愿者的随机、双盲、交叉、安慰剂对照研究中，研究了新型5-羟色胺3（5-HT3）受体拮抗剂BRL 46470A（0.1微克、0.01毫克、1毫克或50毫克）和劳拉西泮（2.5毫克）单剂量对心理测量性能和脑电图（EEG）的影响。2. 有强有力的证据表明，劳拉西泮对脑电图有显著影响，增加了1赫兹至7赫兹以及13赫兹至20赫兹波段的功率，同时降低了8赫兹至12赫兹波段的功率。根据心理测量性能和主观指标评估，劳拉西泮还导致白天功能受损。3. 相比之下，几乎没有证据表明BRL 46470A对脑电图有任何影响，或者它会损害白天功能。
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