蟾蜍慢肌纤维中的钾离子和钙离子电导
Potassium and calcium conductance in slow muscle fibres of the toad.
作者信息
Stefani E, Uchitel O D
出版信息
J Physiol. 1976 Feb;255(2):435-48. doi: 10.1113/jphysiol.1976.sp011288.
Abstract
Slow muscle fibres in isotonic potassium sulphate saline could be easily repolarized to -90 mV. From this membrane potential a regenerative response could be elicited with short depolarizing pulses. 2. This response is blocked by TEA, suggesting that potassium is the main ion involved. 3. In the presence of TEA, a transient depolarization is recorded when the steady hyperpolarization is withdrawn. This anode break response is dependent upon the external calcium and is blocked by cobalt, suggesting that it is due to a calcium conductance. 4. The membrane conductance change was continuously recorded with short pulses at the end of the hyperpolarization. The membrane conductance decayed with at least two components with an average t1/2 of 1-2 and 6-8 sec. TEA blocked the slow component, and the fast one was dependent upon calcium and was blocked by cobalt.
摘要
在等渗硫酸钾盐溶液中的慢肌纤维能够很容易地复极化至-90毫伏。从这个膜电位，用短的去极化脉冲能够引发再生反应。2. 这种反应被四乙铵阻断，这表明钾是主要参与的离子。3. 在四乙铵存在的情况下，当稳定的超极化被撤销时会记录到一个短暂的去极化。这种阳极断电反应依赖于细胞外钙并且被钴阻断，这表明它是由于钙电导所致。4. 在超极化结束时用短脉冲持续记录膜电导变化。膜电导至少以两个成分衰减，平均半衰期为1至2秒和6至8秒。四乙铵阻断慢成分，而快成分依赖于钙并且被钴阻断。
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