用阿霉素（NSC-1231127）治疗实体P815x2小鼠肥大细胞瘤：毒性限制
Treatment of solid P815x2 murine mastocytoma with adriamycin (NSC-1231127): toxity limitations.
作者信息
Schenken L L, Poulakos L, Hagemann R F, Burholt D, Lesher S
出版信息
J Natl Cancer Inst. 1976 Mar;56(3):683-5. doi: 10.1093/jnci/56.3.683.
PMID:815561
Abstract
The efficacy of adriamycin (NSC-123127), given as weekly or as 5-day-per-week doses, on the control of solid P815X2 murine mastocytomas was severely limited by hematopoietic and gastrointestinal toxicity. Although daily or weekly drug schedules both elicited dose responsiveness in terms of tumor control, no dose level of drug increased the life-span of tumor bearing animals.
摘要
阿霉素（NSC-123127）以每周给药或每周给药5天的方式给药时，对实体P815X2小鼠肥大细胞瘤的控制效果受到造血系统和胃肠道毒性的严重限制。尽管每日或每周给药方案在肿瘤控制方面均表现出剂量反应性，但没有任何药物剂量水平能延长荷瘤动物的寿命。
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