Poulakos L, Schenken L L, Hagemann R F, Burholt D R, Lesher S
J Natl Cancer Inst. 1975 May;54(5):1103-5. doi: 10.1093/jnci/54.5.1103.
A treatment concept for the control of tumor growth utilized weekday radiotherapy and weekend chemotherapy. Mice were given sc injections of P815X2 mastocytoma cells on the lower back (day 0) and separated into the following treatment groups: 5-day/week X-irradiation, adriamycin alone at either 5 mg/kg body wt (days 6 and 13) or 2 mg/kg (days 5, 12, and 19), and combined radiotherapy and chemotherapy. Untreated controls had a mean tumor volume of 2.77 cm-3 and a mean survival time of 24 days. Adriamycin alone at 5 mg/kg resulted in an eventual tumor of 70 percent of the control value at death, whereas at 2mg/kg the tumor volume was 60 percent of control. After radiotherapy only, tumor size was 52 percent of control. Irradiation plus either 5 or 2 mg drug per kg body wt resulted in tumor volumes of 23 and 30 percent, respectively, of control values. Although no treatment regimen prolonged survival, the marked reduction in local tumor growth with combination therapy indicates that it may be a useful concept in future cancer therapy.
一种控制肿瘤生长的治疗理念采用了工作日放疗和周末化疗的方式。在小鼠下背部皮下注射P815X2肥大细胞瘤细胞（第0天），并将其分为以下治疗组：每周5天进行X射线照射、单独使用阿霉素，剂量为5mg/kg体重（第6天和第13天）或2mg/kg（第5天、第12天和第19天），以及放疗与化疗联合治疗。未治疗的对照组平均肿瘤体积为2.77cm³，平均生存时间为24天。单独使用5mg/kg阿霉素导致死亡时最终肿瘤体积为对照组的70%，而2mg/kg时肿瘤体积为对照组的60%。仅放疗后，肿瘤大小为对照组的52%。每千克体重照射加5mg或2mg药物导致肿瘤体积分别为对照组的23%和30%。尽管没有治疗方案能延长生存期，但联合治疗使局部肿瘤生长显著减少，这表明它可能是未来癌症治疗中的一个有用理念。
