Schenken L L, Poulakos L, Hagemann R F
Br J Cancer. 1975 Feb;31(2):228-36. doi: 10.1038/bjc.1975.29.
Several radiotherapeutic schedules compatible with continued structural-functional integrity of the gastrointestinal (GI) mucosa were compared utilizing the P815X2 murine mastocytoma grown as a solid subcutaneous tumour. Both the tumour and underlying normal tissues were irradiated during the treatments. The tumour exhibited a Do that increased from 210 rad to 397 rad as the tumour aged and in all instances demonstrated minimal shoulders in survival curves. In spite of a relative radioresistance of cells within the solid tumour, quite effective control of localized disease could be accomplished with radiotherapy schemes compatible with GI tolerance limits. Schedules evaluated utilizing this model included acute exposures to 1122 rad, daily exposure to 187 rad, 5 days/week exposures to 281 rad, twice weekly exposures (561 rad on Mondays and 374 rad on Thursdays) and a high dose, two fractions per day, schedule. Tumours were followed for changes in growth patterns during these schedules. Efficacy of tumour control was determined and schedules were compared on this basis. Aggressive radiotherapy approaching the tolerance limits of any of the fractionation schemes proved most effective.
利用作为实体皮下肿瘤生长的P815X2小鼠肥大细胞瘤，比较了几种与胃肠道（GI）黏膜持续结构-功能完整性相容的放射治疗方案。在治疗过程中，肿瘤及其下方的正常组织均接受了照射。随着肿瘤老化，肿瘤的Do值从210拉德增加到397拉德，并且在所有情况下，生存曲线均显示出最小的坪区。尽管实体瘤内的细胞具有相对的放射抗性，但采用与胃肠道耐受极限相容的放射治疗方案仍可有效控制局部疾病。利用该模型评估的方案包括急性暴露于1122拉德、每天暴露于187拉德、每周5天暴露于281拉德、每周两次暴露（周一561拉德，周四374拉德）以及高剂量、每天两次分割的方案。在这些方案实施期间，对肿瘤的生长模式变化进行了跟踪。确定了肿瘤控制的疗效，并在此基础上比较了各个方案。接近任何一种分割方案耐受极限的积极放射治疗被证明是最有效的。
