King M J
International Blood Group Reference Laboratory, Bristol, UK.
Biochim Biophys Acta. 1994 Apr 5;1197(1):15-44. doi: 10.1016/0304-4157(94)90017-5.
Human erythrocyte blood group antigens can be broadly divided into carbohydrates and proteins. The carbohydrate-dependent antigens (e.g., ABH, Lewis, Ii, P1, P-related, T and Tn) are covalently attached to proteins and/or sphingolipids, which are also widely distributed in body fluids, normal tissues and tumors. Blood group gene-specific glycosyltransferase regulate the synthesis of these antigens. Protein-dependent blood group antigens (e.g., MNSs, Gerbich, Rh, Kell, Duffy and Cromer-related) are carried on proteins, glycoproteins and proteins with glycosylphosphatidylinositol anchor. The functions of these molecules on human erythrocytes remain unknown; some of them may be involved in maintaining the erythrocyte shape. This review describes the distribution, structures and probable biological functions of some of these antigens in normal and pathological conditions.
人类红细胞血型抗原大致可分为碳水化合物和蛋白质两类。依赖碳水化合物的抗原（如ABH、Lewis、Ii、P1、P相关、T和Tn）共价连接于蛋白质和/或鞘脂，这些物质也广泛分布于体液、正常组织和肿瘤中。血型基因特异性糖基转移酶调节这些抗原的合成。依赖蛋白质的血型抗原（如MNSs、Gerbich、Rh、Kell、Duffy和Cromer相关）存在于蛋白质、糖蛋白和带有糖基磷脂酰肌醇锚定的蛋白质上。这些分子在人类红细胞上的功能尚不清楚；其中一些可能参与维持红细胞的形状。本综述描述了其中一些抗原在正常和病理条件下的分布、结构及可能的生物学功能。
