Iskra M, Patelski J, Majewski W
Department of General Chemistry, Karol Marcinkowski University of Medical Sciences, Poznań, Poland.
J Trace Elem Med Biol. 1997 Dec;11(4):248-52. doi: 10.1016/S0946-672X(97)80020-X.
Changes in copper concentration in the arterial wall are important because of cross-linkage formation in collagen and elastin. The breakdown of the elastic layer is characteristic for aneurysm and is affected by the abnormalities in copper metabolism. This study was undertaken to evaluate Ca, Mg, Zn and Cu concentrations and their relationships in the arterial wall, serum and calcified plaque in atherosclerosis obliterans (AO) and abdominal aortic aneurysm (AA). Samples of the aorta wall were obtained at the endarterectomy in AO and the vascular reconstruction in AA. Elements were determined by means of atomic absorption spectrometry. Serum concentrations of Zn and Cu were higher and that of Ca lower in AO as compared to AA and the controls. Arterial concentrations of Zn, Cu and Mg were higher in AO as compared to AA. The ratios of element concentrations in serum (Ca/Mg, Ca/Zn and Mg/Cu) were higher in serum in AA than in AO. Positive correlations were calculated for Ca and Mg (r > or = 0.74), Ca and Zn (r > or = 0.73), Mg and Zn (r > or = 0.90) in the arterial wall in AO and AA. Low but significant correlation was calculated for Cu concentrations between serum and the arterial wall in AA (r = 0.43). Concentrations of Ca, Mg, Zn and Cu were higher in plaque than in the surrounding tissue. The results indicate differences in arterial and serum concentrations of Ca, Mg, Zn and Cu between AO and AA and the accumulation of these elements in the plaque rather than in the surrounding vascular tissue.
动脉壁中铜浓度的变化很重要，因为它会导致胶原蛋白和弹性蛋白交联形成。弹性层的破坏是动脉瘤的特征，并且受铜代谢异常的影响。本研究旨在评估闭塞性动脉硬化（AO）和腹主动脉瘤（AA）患者动脉壁、血清及钙化斑块中钙、镁、锌和铜的浓度及其相互关系。AO患者在动脉内膜切除术中获取主动脉壁样本，AA患者在血管重建术中获取样本。通过原子吸收光谱法测定元素含量。与AA患者及对照组相比，AO患者血清中锌和铜的浓度较高，钙的浓度较低。与AA患者相比，AO患者动脉中锌、铜和镁的浓度较高。AA患者血清中元素浓度的比值（钙/镁、钙/锌和镁/铜）高于AO患者。在AO和AA患者的动脉壁中，钙与镁（r≥0.74）、钙与锌（r≥0.73）、镁与锌（r≥0.90）之间呈正相关。AA患者血清与动脉壁中铜浓度之间存在低但显著的相关性（r = 0.43）。斑块中钙、镁、锌和铜的浓度高于周围组织。结果表明，AO和AA患者动脉及血清中钙、镁、锌和铜的浓度存在差异，且这些元素在斑块中而非周围血管组织中蓄积。
