Kovcin V, Jelić S, Babović N, Tomasević Z
Institute of Oncology and Radiology, Belgrade, Yugoslavia.
Support Care Cancer. 1994 Jan;2(1):71-3. doi: 10.1007/BF00355243.
Although the pain-relieving activity of salmon calcitonin has been mainly demonstrated for painful bone metastases it has been postulated that the drug possesses a central analgesic activity which is independent of the opiate receptor system. Thus, 16 patients with neuropathic cancer pain due to radicular compression by extraskeletal metastases, and without the possibility of any specific anticancer treatment, entered the study. Of the 16, 11 were pretreated with opiate-type analgesics. Salmon calcitonin was applied once daily at a dose of 200 IU in 500 ml 0.9% NaCl infused over 1 h. The total duration of the treatment was 20 days. The pain-relieving effect was classified as very good, good, moderate and bad; in 10 patients it was described as bad, in 2 as moderate in 2 as good and in 2 as very good. The drug failed in 9/11 opiate-pretreated patients. It is suggested that salmon calcitonin pain-relieving activity might depend on the tumor type, previous pain-relieving drug intake and site of metastatic disease.
尽管鲑鱼降钙素的止痛活性主要在骨转移疼痛中得到证实，但据推测该药物具有独立于阿片受体系统的中枢镇痛活性。因此，16例因骨骼外转移引起神经根受压而患有神经性癌痛且无法进行任何特异性抗癌治疗的患者进入了该研究。这16例患者中，有11例曾接受过阿片类镇痛药预处理。鲑鱼降钙素以200 IU的剂量每日给药一次，加入500 ml 0.9%氯化钠中，在1小时内输注完毕。治疗总时长为20天。止痛效果分为非常好、好、中等和差；10例患者的效果被描述为差，2例为中等，2例为好，2例为非常好。该药物在11例接受过阿片类药物预处理的患者中有9例治疗失败。提示鲑鱼降钙素的止痛活性可能取决于肿瘤类型、先前的止痛药物使用情况以及转移病灶的部位。
