Jelić S, Borkovacki R, Babović N, Kovcin V, Milanović N
Institut za onkologiju i radiologiju Srbije, Beograd.
Vojnosanit Pregl. 1995 Mar-Apr;52(2):151-4.
In 16 patients with pain caused by diffuse osteolytic or osteoplastic-osteolytic metastases, salmon calcitonin was used as pain relieving treatment. All patients were pretreated with opiate type analgesics without a satisfactory effect. In 2 patients it was possible to withdraw completely previous opiate intake. In most of the patients the analgesic effect of salmon calcitonin consisted in decrease of pain with identical or decreased intake of opiate type analgesics. In 3 patients the pain relieving treatment with salmon calcitonin completely failed. Our investigation seems to demonstrate that there is a subpopulation of patients with bone metastases, resistant to opiate type analgesics, in which salmon calcitonin can be administered as an additional useful pain relieving drug.
在16例因弥漫性溶骨性或成骨性-溶骨性转移引起疼痛的患者中，使用鲑鱼降钙素进行止痛治疗。所有患者均预先使用阿片类镇痛药治疗，但效果不佳。2例患者得以完全停用先前使用的阿片类药物。在大多数患者中，鲑鱼降钙素的镇痛作用表现为疼痛减轻，同时阿片类镇痛药的摄入量相同或减少。3例患者使用鲑鱼降钙素进行止痛治疗完全无效。我们的研究似乎表明，存在一部分对阿片类镇痛药耐药的骨转移患者，在这些患者中，鲑鱼降钙素可作为一种额外有效的止痛药物使用。
