Imamura S, Kusunoki Y, Takifuji N, Kudo S, Matsui K, Masuda N, Takada M, Negoro S, Ryu S, Fukuoka M
Department of Pathology, Kumamoto University School of Medicine, Japan.
Cancer. 1994 Mar 15;73(6):1608-14. doi: 10.1002/1097-0142(19940315)73:6<1608::aid-cncr2820730611>3.0.co;2-1.
Thirty-nine roentgenologically occult lung cancers in 29 patients were treated using photodynamic therapy (PDT) and/or thoracic radiotherapy (TRT) from January 1986 to March 1992. With the exception of one mixed-tumor case, all were squamous cell carcinomas.
Initial PDT achieved complete responses in 25 of 39 (64%) of the cancers. Of the remaining 14 cancers that showed less than complete response (CR), 10 of the 14 (71.4%) showed a CR when subsequently treated with TRT, yielding an overall CR rate of 89.7% for cancers treated. Although nine patients experienced recurrences, six of these had CR when treated with PDT and/or TRT. To date, 22 patients are alive. Causes of death in the patients enrolled in this study are as follows: pyothorax (2); heart failure due to pulmonary hypertension (1); chronic respiratory insufficiency (1); subsequent primary brain cancer (1); and subsequent primary lung cancer (1). Only one died of primary lung cancer.
These findings suggest that PDT and/or TRT may be used as an alternative to surgery in the treatment of selected patients with roentgenologically occult lung cancer.
1986年1月至1992年3月期间，对29例患者的39例X线隐匿性肺癌采用光动力疗法（PDT）和/或胸部放疗（TRT）进行治疗。除1例混合瘤病例外，其余均为鳞状细胞癌。
最初的PDT使39例癌症中的25例（64%）达到完全缓解。其余14例未达到完全缓解（CR）的癌症中，14例中的10例（71.4%）在随后接受TRT治疗时达到CR，接受治疗的癌症总体CR率为89.7%。尽管9例患者出现复发，但其中6例在接受PDT和/或TRT治疗时达到CR。迄今为止，22例患者存活。本研究中患者的死亡原因如下：脓胸（2例）；肺动脉高压导致的心力衰竭（1例）；慢性呼吸功能不全（1例）；随后发生的原发性脑癌（1例）；以及随后发生的原发性肺癌（1例）。仅1例死于原发性肺癌。
这些结果表明，PDT和/或TRT可作为手术的替代方法，用于治疗部分X线隐匿性肺癌患者。
